Nanoparticle-Based Modification of the DNA Methylome: A Therapeutic Tool for Atherosclerosis?

Cardiovascular epigenomics is a relatively young field of research, yet it providing novel insights into gene regulation in the atherosclerotic arterial wall. That information already pointing to new avenues for atherosclerosis (AS) prevention and therapy. In parallel, advances nanoparticle (NP) technology allow effective targeting drugs bioactive molecules vascular The partnership NP epigenetics AS just beginning promises produce exciting candidate treatments. Here, we briefly discuss most relevant recent two fields. We focus on DNA methylation, as methylome that condition better understood comparison with rest cardiovascular disease field. particular, review NP-based delivery systems their use modification inflammation. also address methyltransferase inhibitors Furthermore, emphasize unique challenges designing therapies target epigenome. Lastly, touch issue human exposure industrial NPs its impact epigenome reminder undesired effects any therapy must avoid be apt secondary AS.